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The U.S. Department of Transportation (USDOT) established the Intelligent Vehicle Initiative (IVI) Generation 0 Field Operational Tests (FOT) to demonstrate the effectiveness and encourage the deployment of intelligent vehicle safety systems (IVSS). This paper presents a methodology for estimating potential safety benefits of IVSS from such FOTs. The metric chosen is potential reduction in number of crashes resulting from widespread deployment of the IVSS. The methodology is based on the approach developed by the National Highway Traffic Safety Administration, Federal Highway Administration, and the Volpe National Transportation Systems Center. New features of the methodology include rigorous estimates of crash probabilities combining analytical models with FOT data and detailed investigation of the variability associated with benefits estimates. Although millions of miles will be driven in the IVI Generation 0 FOTs, few crashes are anticipated.