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BioSim is a simulation tool which captures many basic life support functions in an integrated simulation. Conventional analyses can not efficiently consider all possible life support system configurations. Heuristic approaches are a possible alternative. In an effort to demonstrate efficacy, a validating experiment was designed to compare the configurational optima discovered by heuristic approaches and an analytical approach. Thus far, it is clear that a genetic algorithm finds reasonable optima, although an improved fitness function is required. Further, despite a tight analytical fit to data, optimization produces disparate results which will require further validation.