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Fuel properties impact the engine-out emission directly. For some geographic regions where diesel engines can meet emission regulations without aftertreatment, the change of fuel properties will lead to final tailpipe emission variation. Aftertreatment systems such as Diesel Particulate Filter (DPF) and Selective Catalytic Reduction (SCR) are required for diesel engines to meet stringent regulations. These regulations include off-road Tier 4 Final emission regulations in the USA or the corresponding Stage IV emission regulations in Europe. As an engine with an aftertreatment system, the change of fuel properties will also affect the system conversion efficiency and regeneration cycle. Previous research works focus on prediction of engine-out emission, and many are based on chemical reactions. Due to the complex mixing, pyrolysis and reaction process in heterogeneous combustion, it is not cost-effective to find a general model to predict emission shifting due to fuel variation.

With stringent emission regulations, many subsystems that abate engine tailpipe-out emissions become a necessary part for engines. The increased level of complexity poses technical challenges for the quality and reliability for modern engines. Among the spectrum of quality control methodologies, one conventional methodology focuses on every component's quality to ensure that the accumulative deviation is within predetermined limits. This conventional methodology tightens the component tolerance during the manufacturing process and typically results in increased cost. Another conventional methodology that is on the other side of the spectrum focuses on tailoring an engine calibration solution to offset the manufacturing differences. Although the tailored engine calibration solution reduces manufacturing cost for components, it increases the development and validation cost for engines. Given the cost and time constraints, system integration plays an important role in engine development.