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This paper presents newly developed capabilities for the virtual human Santos™. Santos is an avatar that has extensive modeling and simulation features. It is a digital human with 109 degrees of freedom (DOF), an optimization-based method, predictive dynamics, and realistic human appearance. The new capabilities include (1) significant progress in predictive dynamics (walking and running), (2) advanced clothing modeling and simulation, (3) muscle wrapping and sliding, and (4) hand biomechanics. With these newly developed functionalities, Santos can simulate various dynamic tasks such as walking and running, investigate clothing restrictions to motion such as joint limits and torques, simulate the musculoskeletal system in real time, predict hand injury by monitoring the joint torques, and facilitate vehicle interior design. Finally, additional on-going projects are summarized.