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Debris in the Orbiter crew compartment of early Shuttle missions created crew health concerns and physiological discomfort, and was the cause of some equipment malfunctions. Debris from Orbiters during flight and processing was analyzed, quantized, and evaluated to determine its source. Records were kept on the amount of debris vacuumed by the crew during on-orbit cleaning and the amount found on air-cooled avionics boxes during ground turnaround. After ground turnaround operations at Kennedy Space Center and Palmdale were reviewed from a facility, materials use, and materials control standpoint, the following remedial steps were taken.