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The shearing and bending injury mechanisms of the knee joint are recognised as two important injury mechanisms associated with car-pedestrian crash accidents. A study on shearing and bending response of the knee joint to a lateral impact loading was conducted with a 3D multibody system model of the lower extremity. The model consists of foot, leg and thigh with concentrated upper body mass. The body elements are connected by joints, including an anatomical knee joint unit that consists of the femur condyles, tibia condyles and tibia1 intercondylar eminence as well as ligaments. The biomechanical properties of the model were derived from literature data. The model was used to simulate two series of previously performed experiments with lower extremity specimens at lateral impact speeds of 15 and 20 km/h.