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Alcohols are potential blending agents for diesel that can be effectively used in compression ignition engines. This work investigates the use of n-butanol as a blending component for diesel fuel using experiments and simulations. Dodecane was selected as a surrogate for diesel fuel and various concentrations of n-butanol were added to study ignition characteristics. Ignition delay times for different n-butanol/dodecane blends were measured using the ignition quality tester at KAUST (KR-IQT). The experiments were conducted at pressure of 21 and 18 bar, temperature ranging from 703-843 K and global equivalence ratio of 0.85. A skeletal mechanism for n-dodecane and n-butanol blends with 203 species was developed for numerical simulations. The mechanism was developed by combining n-dodecane skeletal mechanism containing 106 species and a detailed mechanism for all the butanol isomers.