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This paper presents an overview of a project called “Modelling and Simulation Tools for Systems Integration on Aircraft (MISSION)”. This is a collaborative project being developed under the European Union Clean Sky 2 Program, a public-private partnership bringing together aeronautics industrial leaders and public research organizations based in Europe. The provision of integrated modeling, simulation, and optimization tools to effectively support all stages of aircraft design remains a critical challenge in the Aerospace industry. In particular the high level of system integration that is characteristic of new aircraft designs is dramatically increasing the complexity of both design and verification. Simultaneously, the multi-physics interactions between structural, electrical, thermal, and hydraulic components have become more significant as the systems become increasingly interconnected.