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Reliability-based design optimization accounts for variation. However, it assumes that statistical information is available in the form of fully defined probabilistic distributions. This is not true for a variety of engineering problems where uncertainty is usually given in terms of interval ranges. In this case, interval analysis or possibility theory can be used instead of probability theory. This paper shows how possibility theory can be used in design and presents a computationally efficient sequential optimization algorithm. The algorithm handles problems with only uncertain or a combination of random and uncertain design variables and parameters. It consists of a sequence of cycles composed of a deterministic design optimization followed by a set of worst-case reliability evaluation loops. A crank-slider mechanism example demonstrates the accuracy and efficiency of the proposed sequential algorithm.