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The Indian automotive industry has taken a big leap towards stringent Bharat Stage VI (BS VI) emission standards by year 2020. A digital driven design and development focusing on innovative and commercially viable technologies for combustion and exhaust after-treatment system is the need of the time. One-dimensional (1D) simulation serves as a best alternative to its counterparts in terms of obtaining faster and accurate results, which makes it an ideal tool for carrying out optimization studies at system level. In this work, 1D chemical kinetics modelling and analysis of exhaust after-treatment system (EAT) for a heavy-duty diesel has been performed using GT-Power. Initially, a single site 1D model for a diesel oxidation catalyst (DOC) has been developed and then, a two-site, 1D model for a selective catalytic reduction (SCR) catalyst was also developed based on reactor data.