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This CFD study is aimed at evaluation of the ventilation characteristics within the ISS Node 1 with the Advanced Resistive Exercise Device (ARED) protrusions into ECLS keep-out zones. An assessment of Node 1 airflow characteristics in the presence of the ARED and a human body simulation model has been performed for the current on-orbit configuration of the Node 1 ventilation system. Both the quantitative velocity distribution analysis and qualitative three-dimensional airflow evaluation have shown that the installation of the ARED in the Node 1 radial bay produces a minimal impact on the cabin ventilation characteristics and the crew.