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Lower extremities are the most frequently injured body regions in vehicle-to-pedestrian collisions and such injuries usually lead to long-term loss of health or permanent disability. However, influence of pre-impact posture on the resultant impact response has not been understood well. This study aims to investigate the effects of preimpact pedestrian posture on the loading and the kinematics of the lower extremity when struck laterally by vehicle. THUMS pedestrian model was modified to consider both standing and mid-stance walking postures. Impact simulations were conducted under three severities, including 25, 33 and 40 kph impact for both postures. Global kinematics of pedestrian was studied. Rotation of the knee joint about the three axes was calculated and pelvic translational and rotational motions were analyzed.