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The effects of both the cosmic ray heavy ion exposures and the intense trapped electron exposures are examined with respect to impact on cellular system survival on exterior spacecraft surfaces as well as at interior (shielded) locations for a sample mission to Jupiter’s moons. Radiation transport through shield materials and subsequent exposures are calculated with the established Langley heavy ion and electron deterministic codes. In addition to assessing fractional DNA single and double strand breaks, a variety of cell types are examined that have greatly differing radio-sensitivities. Finally, implications as to shield requirements for controlled biological experiments are discussed.