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The appropriate role of human testing in life support systems design has been a key concern for human spacecraft development. This discussion intensified over the past one and a half years as the International Space Station (ISS) evaluated the risk associated with the baseline program while conducting cost and schedule convergence activities. The activity was carried from the traditional top-level discussion to evaluation of the specific Space Station Life Support concerns associated with human interaction, weighed against cost impacts. This paper details the results of this activity, providing the rationale for the present ISS approach.