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In preparation for the contract award of the Crew Exploration Vehicle (CEV), the National Aeronautics and Space Administration (NASA) produced two design reference missions for the vehicle. The design references used teams of engineers across the agency to come up with two configurations. This process helped NASA understand the conflicts and limitations in the CEV design, and investigate options to solve them.

NASA's Constellation Program, which includes the mission objectives of establishing a permanently-manned lunar Outpost, and the exploration of Mars, poses new and unique challenges for human life support systems that will require solutions beyond the Shuttle and International Space Station state of the art systems. In particular, the requirement to support crews for extended durations at the lunar outpost with limited resource resupply capability will require closed-loop regenerative life support systems with minimal expendables. Planetary environmental conditions such as lunar dust and extreme temperatures, as well as the capability to support frequent and extended-duration Extra-vehicular Activity's (EVA's) will be particularly challenging.

Exploration Life Support (ELS) is a technology development project under the National Aeronautics and Space Administration's (NASA) Exploration Technology Development Program. The ELS Project's goal is to develop and mature a suite of Environmental Control and Life Support System (ECLSS) technologies for potential use on human spacecraft under development in support of U.S. Space Exploration Policy. Technology development is directed at three major vehicle projects within NASA's Constellation Program: the Orion Crew Exploration Vehicle (CEV), the Altair Lunar Lander and Lunar Surface Systems, including habitats and pressurized rovers. The ELS Project includes four technical elements: Atmosphere Revitalization Systems, Water Recovery Systems, Waste Management Systems and Habitation Engineering, and two cross cutting elements, Systems Integration, Modeling and Analysis, and Validation and Testing.

Sublimators have been used for heat rejection for a variety of space applications including the Apollo Lunar Module and the Extravehicular Mobility Unit (EMU). Sublimators are excellent candidates for heat rejection devices on future vehicles like the Crew Exploration Vehicle (CEV), the Lunar Surface Access Module (LSAM), and future spacesuits. One of the drawbacks of previous designs was sensitivity to contamination in the feedwater. Undissolved contaminants can be removed with filters, but dissolved contaminants would be left in the pores of the porous plates in which the feedwater freezes and sublimates. These contaminants build up and clog the relatively small pores (~3–6 μm), thereby blocking the flow of the feedwater, reducing the available area for freezing and sublimation, and degrading the performance of the sublimator. For the X-38 program, a new sublimator design was developed by NASA-JSC that is less sensitive to contaminants.