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An airplane passenger seat, like other seats in transportation, is used by thousands or millions of people. The seat should be designed to accommodate the maximum number of a target population by taking into account the variability of body size and also the environment’s constraints. Thanks to a fully adjustable experimental seat recently built at IFSTTAR, data of the preferred seat profile and compressed seat pan surface were collected in function of seat pan and backrest angle from a sample of 36 differently sized participants. Parametric models were obtained to predict optimal seat profile parameters in function of a sitter’s anthropometric characteristics, seat pan angle and seat back angle. Using a population simulation approach, a sample of 500 males and 500 females were generated randomly based on the distribution of relevant anthropometric dimensions.