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The purpose in doing probabilistic structural analysis is to provide the designer with a more realistic ability to assess the importance of uncertainty in the structural response. This paper provides an overview of the methodology and discusses validation of modular structural analysis packages capable of predicting the probabilistic response distribution for key structural variables such as stress, displacement, natural frequencies, buckling loads, transient responses, etc. The structural analysis solution is in terms of the cumulative distribution function (CDF). Probabilistic structural analysis methods (PSAM) can be used to estimate structural safety and reliability, while providing the engineer with information on the confidence that should be given to the predicted behavior.