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There are a large number of uncertainties in engineering design, and the accumulated uncertainties will enlarge the overall failure probability of the structure system. Therefore, structural design considering uncertainties has good guiding significance for improving the reliability of engineering structures. To address this issue, the dynamic-static structural topology optimization is established and reliability-based topology optimization with decoupling format is conducted in this study. The design point which satisfying the constraint of the target reliability indicator is obtained according to the reliability indicators of the first-order reliability method, and the uncertain design variables are modified into a deterministic variable according to the sensitivity information.