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The development and calibration of exhaust aftertreatment (EAT) systems for the most diverse applications of diesel powertrain concepts requires EAT models, capable of performing concept analysis as well as control and OBD system development and calibration. On the concept side, the choice of an application-specific EAT layout from a wide technology selection is driven by a number of requirements and constraints. These include statutory requirements regarding emissions of criteria pollutants and greenhouse gases (GHG), technical constraints such as engine-out emissions and packaging, as well as economic parameters such as fuel consumption, and EAT system and system development costs. Fast and efficient execution of the analysis and multi-criteria system optimization can be done by integrating the detailed EAT models into a total system simulation.