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The assembly complete Environmental Control and Life Support (ECLS) system for the International Space Station (ISS) will consist of components and subsystems in both the U.S. and International partner elements which together will perform the functions of Temperature and Humidity Control (THC), Atmosphere Control and Supply (ACS), Atmosphere Revitalization (AR), Water Recovery and Management (WRM), Waste Management (WM), Fire Detection and Suppression (FDS), and Vacuum System (VS) for the station. Due to limited resources available on ISS, detailed attention is given to minimizing and tracking all resources associated with all systems, beginning with estimates during the hardware development phase through measured actuals when flight hardware is built and delivered. A comprehensive summary of resources consumed by the U.S.

NASA's Constellation Program, which includes the mission objectives of establishing a permanently-manned lunar Outpost, and the exploration of Mars, poses new and unique challenges for human life support systems that will require solutions beyond the Shuttle and International Space Station state of the art systems. In particular, the requirement to support crews for extended durations at the lunar outpost with limited resource resupply capability will require closed-loop regenerative life support systems with minimal expendables. Planetary environmental conditions such as lunar dust and extreme temperatures, as well as the capability to support frequent and extended-duration Extra-vehicular Activity's (EVA's) will be particularly challenging.

In preparation for the contract award of the Crew Exploration Vehicle (CEV), the National Aeronautics and Space Administration (NASA) produced two design reference missions for the vehicle. The design references used teams of engineers across the agency to come up with two configurations. This process helped NASA understand the conflicts and limitations in the CEV design, and investigate options to solve them.