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Classical blunt thoracic impacts have involved midsternal anteroposterior loadings to an upright-positioned subject. Data on the sensitivity of human cadaver and/or animal model biomechanical and injury responses to blunt loadings at different sternal locations is needed to evaluate the efficacy of current injury-potential guidelines for nonsite-specific frontal impacts. In addition, the biomechanics and injury mechanisms associated with lateral impacts constitute a subject of increasing consideration for occupant protection. Twelve anesthetized pigs were subjected to various blunt frontal or a right-side impact to assess biomechanical and injury response differences in a living animal model.