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The United States Propulsion Module (USPM) is a pressurized element and provides reboost, propulsive attitude control, control moment gyro (CMG) desaturation, and collision avoidance functions for the International Space Station (ISS). The USPM will dock with Node 2 at the pressurized mating adapter-2 (PMA-2). After docking with PMA-2, the USPM will provide mechanical and structural interfaces to the Space Shuttle, along with facilities for crew transfer and receiving resupply oxygen, nitrogen, water, helium, and propellants from the Space Shuttle. It is essential that the USPM maintain a safe and functional life support system during crew member passage and maintenance activities. It is complex and costly to design an operational system to satisfy all ISS requirements. This paper details an innovative USPM environmental control and life support system (ECLSS) design that satisfies all ISS requirements at a reduced cost.