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Further growth of diesel engines in the light-duty and heavy-duty vehicular market is closely linked to the potential health risks of diesel exhaust. The California Air Resources Board and the Office of Environmental Health Hazard Assessment have identified diesel exhaust as a toxic air contaminant. The International Agency for Research on Cancer concluded that diesel particulate is a probable human carcinogen [1]. Cleaner burning liquid fuels, such as those derived from natural gas via the Fischer-Tropsch (FT) process, offer a potentially economically viable alternative to standard diesel fuel while providing reduced particulate emissions. Further understanding of FT operation may be realized by investigating the differences in toxicity and potential health effects between particulate matter(PM) derived from FT fuel and that derived from standard Federal diesel No. 2 (DF).