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Currently the U.S. is sponsoring production of radioisotope thermoelectric generators (RTGs) for the Cassini mission to Saturn; the SP-100 space nuclear reactor power system for NASA applications; a thermionic space reactor program for DoD applications as well as early work on nuclear propulsion. In an era of heightened public concern about having successful space ventures it is important that a full understanding be developed of what it means to “flight qualify” a space nuclear system. As a contribution to the ongoing work this paper reviews several qualification programs, including the general-purpose heat source radioisotope thermoelectric generators (GPHS-RTGs) as developed for the Galileo and Ulysses missions, the SNAP-10A space reactor, the Nuclear Engine for Rocket Vehicle Applications (NERVA), the F-1 chemical engine used on the Saturn-V, and the Space Shuttle Main Engines (SSMEs). Similarities and contrasts are noted.

For reasons of safety as well as cost, increasingly lengthy space missions at unprecedented distances from Earth in the 21st century will require reductions in consumables and increases in the autonomy of spacecraft life support systems. Advanced life support technologies can increase mission productivity and enhance science yield by achieving reductions in the mass, volume, and power required to support human needs for long periods of time in sterile and hostile environments. Current investment in developing advanced life support systems for orbital research facilities will increase the productivity of these relatively near-term missions, while contributing to the technology base necessary for future human exploration missions.