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Life sciences research facilities planned for the U.S. Space Station will accommodate life sciences investigations addressing the influence of microgravity on living organisms. Current projects within the Life Sciences Space Station Program (LSSSP), the Life Sciences Space Biology (LSSB) and Extended Duration Crew Operations (EDCO) projects, will explore the physiological, clinical, and sociological implications of long duration space flight on humans and the influence of microgravity on other biological organisms/systems. Initially, the primary research will emphasize certifying man for routine 180-day stays on the Space Station. Operational crew rotations of 180 days or more will help reduce Space Station operational costs and minimize the number of Space Transportation System (STS) shuttle flights required to support Space Station.