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This paper addresses fire and post-fire operational principles and techniques for extinguishing fire events aboard the US Segment of the International Space Station (ISS) through assembly mission 7A. Included is a brief description of ISS fire detection, suppression and cleanup assets. The paper reviews several fireground management fundamentals, including command and control, pre-fire planning, and the use of standard operating procedures. The majority of the paper describes fire detection, response and cleanup management and procedures, and their employment in several US fire scenarios. The paper concludes with a review of procedure validation and training techniques, and areas of open work.