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The reduction in nitrogen oxides (NOx) emissions from heavy-duty diesel engines requires the development of more advanced combustion and control technologies to minimize the total cost of ownership (TCO), which includes both the diesel fuel consumption and the aqueous urea solution used in the selective catalytic reduction (SCR) aftertreatment system. This drives an increased need for highly efficient and clean internal combustion engines. One promising combustion strategy that can curb NOx emissions with a low fuel consumption penalty is to simultaneously reduce the in-cylinder gas temperature and pressure. This can be achieved with Miller cycle and by lowering the in-cylinder oxygen concentration via exhaust gas recirculation (EGR). The combination of Miller cycle and EGR can enable a low TCO by minimizing both the diesel fuel and urea consumptions.