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A methodology for predicting the fatigue initiation life in metals experiencing multiaxial non-proportional loading is presented. The methodology utilizes nonlinear finite-element analysis to determine the stress distribution of the loaded component. This distribution is used in conjunction with a physically based damage law to determine the cycles to failure. The damage law is based on the fatigue prediction method introduced by Dang Van [1], and further developed by Papadopoulos [2] and Morel [3]. The fatigue damage initiation is treated as the persistent crystalline slip phenomenon taking place on the order of a grain or few grains. The damage variable is chosen to be the accumulated plastic strain at this scale. The initiation life is determined when the damage variable reaches a critical value. The developed methodology is applicable to both in-phase and out-of-phase loading, without any empirical adjustment parameter.