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Strain-controlled low-cycle fatigue (LCF) experiments were conducted on ductile cast iron at total strain rates of 1.2/min, 0.12/min and 0.012/min in a temperature range of RT ~ 800°C. An integrated creep-fatigue (ICF) life prediction framework is proposed, which embodies a deformation mechanism based constitutive model and a thermomechanical damage model. The constitutive model is based on the decomposition of inelastic deformation into plasticity and creep mechanisms, which can describe both rate-independent and rate-dependent cyclic responses under wide strain rate and temperature conditions. The damage model takes into consideration of i) plasticity-induced fatigue, ii) intergranular embrittlement, iii) creep and iv) oxidation. Each damage form is formulated based on the respective physical mechanism/strain.