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The design and development of new biologically inspired technologies based on intelligent materials that are capable of sensing the levels of target biomolecules and, if needed, trigger appropriate countermeasures to regulate biological processes and rhythms of the astronauts is being undertaken in our laboratories. This is accomplished by coupling biologically inspired sensors that monitor the levels of the target biomolecules with intelligent polymeric materials that can regulate the release of a countermeasure. The technology developed here integrates sensors and artificial muscle material into a self-regulating device that can perform with minimal crew intervention. Further, it takes advantage of microfabrication technology to construct lightweight and robust responsive delivery systems. These “intelligent” devices address the need for the control and regulation of biological processes and rhythms under spaceflight conditions.