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This paper presents an integrated method for rapid modeling, simulation and virtual evaluation of the interface pressure between driver human body and seat. For simulation of the body-seat interaction and for calculation of the interface pressure, besides body dimensions and material characteristics an important aspect is the posture and position of the driver body with respect to seat. In addition, to ensure accommodation of the results to the target population usually several individuals are simulated, whose body anthropometries cover the scope of the whole population. The multivariate distribution of the body anthropometry and the sampling techniques are usually adopted to generate the individuals and to predict the detailed body dimensions. In biomechanical modeling of human body and seat, the correct element type, the rational settings of the contacts between different parts, the correct exertion of the loads to the calculation field, etc., are also crucial.