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Social stressors in long-duration spaceflight (LDSF) have serious implications for crew effectiveness and mission safety. This paper reviews potential stressors and presents habitat and organizational design considerations to reduce perceived demand from social stressors in four areas: privacy and personal space, isolation, interpersonal interactions, and cultural differences. Results can serve as guidelines for the design of future LDSF missions and spacecraft, and will benefit attempts to develop an accurate model of stress in the spaceflight domain.