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Measurement of particle number was introduced in the Euro 5/6 light duty vehicle emissions regulation. Due to the complex nature of combustion exhaust particles, and to transportation, transformation and deposition mechanisms, such type of measurement is particularly complex, and regression analysis is commonly used for the comparison of different measurement systems. This paper compares various commercial instruments, developing a correlation analysis focused on PN (Particle Number) measurement, and isolating the factors that mainly influence each measuring method. In particular, the experimental activity has been conducted to allow critical comparisons between measurement techniques that are imposed by current regulations and instruments that can be used also on the test cell. The paper presents the main results obtained by analyzing instruments based on different physical principles, and the effects of different sampling locations and different operating parameters.