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Following the development of new technologies in Vehicle Thermal Management aiming to both enhancing the MAC System efficiency and reducing the thermal load to be managed, a prediction tool based on the AMEsim platform was developed at Advanced PD EMEA. This tool is dedicated to predict the effect of the implementation of sensors monitoring both the relative humidity and the carbon dioxide (CO2) concentration (taking into account passengers' generated moisture and CO2). This model implemented with the usual comfort inputs (CO2 and RH acceptable ranges) considers the system variables influencing the comfort and predicts the increase of both RH and CO2 concentration in the cabin compartment in any driving cycle depending on the number of occupants.