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Periprosthetic fractures refer to the fractures that occur in the vicinity of the implants of joint replacement arthroplasty. Most of the fractures during an automotive frontal collision involve the long bones of the lower limbs (femur and tibia). Since the prevalence of persons living with lower limb joint prostheses is increasing, periprosthetic fractures that occur during vehicular accidents are likely to become a considerable burden on health care systems. It is estimated that approximately 4.0 million adults in the U.S. currently live with Total Knee Replacement (TKR) implants. Therefore, it is essential to study the injury patterns that occur in the long bone of a lower limb containing a total knee prosthesis. The aim of the present study is to develop an advanced finite element model that simulates the possible fracture patterns that are likely during vehicular accidents involving occupants who have knee joint prostheses in situ.