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A finite element (FE) model that can predict impact response and injuries to a human pelvis and lower limb was developed in PAM-CRASH™ by accurately representing human anatomical structures. In our previous study, three-dimensional (3D) geometry of the thigh, leg and knee joint was developed based on MRI scans from a human volunteer. 3D geometry of a bony pelvis created in this study was based on CT scans from a Post Mortem Human Subject (PMHS). The model was validated using published quasi-static and dynamic test results with human pelves and lower limbs. The thigh and leg models were validated against recently published dynamic 3-point bending test results with off-center loading. The validation results showed that this model can reproduce force-deflection and moment-deflection responses of a human thigh and leg in various loading conditions along with average force and moment at fracture.