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The present work is concerned with the objective of multi disciplinary design optimization (MDO) of an automotive front end structure using truncated finite element model. A truncated finite element model of a real world vehicle is developed and its efficacy for use in design optimization is demonstrated. The main goal adopted here is minimizing the weight of the front end structure meeting NVH, durability and crash safety targets. Using the Response Surface Method (RSM) and the Design Of Experiments (DOE) technique, second order polynomial response surfaces are generated for prediction of the structural performance parameters such as lowest modal frequency, fatigue life, and peak deceleration value.