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The next generation off-road vehicles will see additional exhaust gas aftertreatment systems, ranging from DOC-SCR only to full DOC-DPF-SCR-AMOX systems. This will increase system complexity and development effort significantly. Emission requirements and the high number of vehicle configurations within the off-road industry will require a new process for development and validation. The introduced model-based approach using physical models of aftertreatment can reduce development effort and cost, improve performance robustness and help to identify performance issues early in the development process. A method to investigate and optimize a large matrix of variations by simulation is introduced. This can lead to a significant reduction in the number of required calibrations and can assist in the development of design specifications for the aftertreatment system. A case study for SCR calibration successfully demonstrates the potential of model-based development.