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Environmental control and life support, ultimately tied to the presence of man in space is one of the key issues of the permanently manned space station initiated by the USA [1], [2].* Europe's participation in that programme is the COLUMBUS programme, the various elements and scenarios of which were subject of extensive studies [3], [4], [5]. This paper is devoted to the Environmental Control and Life Support Subsystem (ECLSS) of the Pressurized Module (PM), the latter being one of the COLUMBUS elements. The present COLUMBUS scenario for the PM comprises the PM either to be attached to the US Space Station (USSS), being one of the core elements of the USSS (integrated PM) or as a Man Tended Free Flyer (MTFF, a PM docked to the Resource Module, RM). The PM in the attached configuration is shown in Fig. 1. The present considerations center on the ECLSS of the PM in attached version which is taken as baseline.