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This paper presents new capabilities of the virtual-human Santos™ introduced last year. Santos™ is an avatar that has extensive modeling and simulation features. It is a digital human model with over 100 degrees-of-freedom (DOF), where the hand model has 25 DOF, direct optimization-based method, and real-human like appearance. The newly developed analysis includes (1) a 25-DOF hand model that is the first step to study hand grasping; (2) posture prediction advances such as multiple end-effectors (two arms, two arms + head + legs), real-time inverse kinematics for posture prediction for any points, vision functionality; (3) dynamic motion prediction with external loads; and (4) musculosteletal modeling that includes determining muscle forces, and muscle stress.