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As emission regulations are becoming increasingly stringent worldwide, multiple exhaust aftertreatment devices are considered in order to minimize diesel engine tailpipe emissions. For the typical diesel applications in developing markets like India, the fuel consumption is a very decisive selling argument for customers. The total cost of ownership needs to be as low as possible. To meet these competing requirements, the aftertreatment and engines must be optimized at the same time as the performance of the one system affects the other. In state-of-the-art calibration processes, the aftertreatment systems are considered separately from the calibration of the thermodynamics. This conventional approach makes it more challenging to achieve a simultaneous optimization of the fuel consumption and tailpipe emissions under transient operating conditions.