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The increased demand in the area of space life sciences necessitates the need for more experimentation hardware with increased capabilities. Due to the high cost of hardware development for space based research, new hardware should be modular in design and suited to handle a variety of different experiments. The fluid handling systems found in experimentation hardware will often share many of the same requirements for different experiments. A design process that can be used for biological fluid handling systems that cover a wide range of experimentation requirements is proposed. Important parameters to be considered when making a trade study for selection of system components will be discussed. This paper will address topics of current research in space life sciences and describe state of the art hardware that is available or under development for use.