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Potable water is undoubtedly one of the most critical resources for the International Space Station (ISS) crews. The amount and quality of this resource, mainly provided to the ISS by the Space Shuttle and Progress, and in the near future by logistic vehicles Automated Transport Vehicle (ATV) and HTV, must be compatible with the crew consumption needs and health-related requirements. For this purpose, potable water must satisfy very stringent quality requirements from chemical and bacteriological point of view. The definition of such requirements, resulting from medical studies, lessons learned, technical constraints, is reached in agreement among ISS International Partners. Two different quality standards are defined, one for the ISS Russian Segment, the other for the US Segment and other International Partners.