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A model is being developed to quantitatively compare and thus assist in the selection of systems and technology options for defined missions envisioned in NASA's Space Exploration Initiative. It consists of a modular top-down hierarchical break-down of the life support systems (LSS) into subsystems, and further break-down of the subsystems into functional elements representing individual processing technologies. A series of papers entitled Human Life Support During Interplanetary Travel & Domicile are planned to describe the techniques and results. Parts I through V have focused on physical/chemical (P/C) Life Support Systems Analysis, with trade-off studies at the systems and technology levels for open and closed loop configurations. This paper discusses an extension to the Generic Modular Flow Schematic (GMFS) for P/C Life Support Systems by the addition of biological (Bio) processes.