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The automotive active infrared detection system is usually applied to the night driver assistance system or the diver attention monitoring system. However, the infrared light emitted by the active infrared detection system can cause damage to retina, cornea and eye crystals. This paper has studied the photobiological safety of the infrared light source used in the automotive active infrared detection system. Although it has been already have the general requirements of photobiological safety in international standards, there is not any requirements for automotive active infrared detection system. The range of the active infrared detection system depends on the radiation intensity of the infrared light source, but too much radiation intensity will cause harm to retina, cornea and eye lens when the infrared light source is too close to eyes.