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One of the key inputs 1-D transient simulation takes is a detailed front end cooling flow map. These maps that are generated using a full vehicle Three-dimensional Computational Fluid Dynamics (3D CFD) model require expensive computational resources and time. This paper describes how an adaptive sampling of the design space allowed the reduction of computational efforts while keeping desired accuracy of the analysis. The idea of the method was to find a pattern of Design of Experiments (DOE) sampling points for 3D CFD simulations that would allow a creation of an approximation model accurate enough to predict output parameter values in the entire design space of interest. Three procedures were implemented to get the optimal sampling pattern.