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The MPLM (Mini Pressurized Logistic Module) is one of the Elements constituting the ISSA (International Space Station Alpha). With respect to the other Elements, the MPLM is not permanently attached to the ISSA, but it is transported by the Orbiter several times from/to the Earth, since its primary use is to resupply and return cargos. The MPLM capability to support the logistic flights is guaranteed during several mission phases (ground, Orbiter transportation, on-orbit docked to the Station). Since the installed cargo can be passive or active, the required MPLM functions are based on the actual flight. This paper presents an overview of the activities performed in Alenia Spazio to identify the criticality and peculiarity of the MPLM mission scenarios from the thermal point of view. The best technical solutions, foreseen up to now, have been implemented in the design to guarantee the reliability requested by such an important and unique Space Station Element.