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Over the next decades to come, fossil fuel powered Internal Combustion Engines (ICE) will still constitute the major powertrains for land transport. Therefore, their impact on the global and local pollution and on the use of natural resources should be minimized. To this end, an extensive fundamental and practical study was performed to evaluate the potential benefits of simultaneously co-optimizing the system fuel-and-engine using diesel as an example. It will be clearly shown that the still unused co-optimizing of the system fuel-and-engine (including advanced exhaust after-treatment) as a single entity is a must for enabling cleaner future road transport by cleaner fuels since there are large, still unexploited potentials for improvements in road fuels which will provide major reductions in pollutant emissions both in vehicles already in the field and even more so in future dedicated vehicles.

The likely transition from today's conventional to future alternative fuels will be discussed. It will be shown that in the very long term renewable fuels might be the most promising road fuels with respect to low CO2 emissions. In the short and medium term, however, liquid alternative fuels will prevail being produced initially from natural gas and later increasingly from biomass. Methanol, Ethanol, GTL Hydrocarbons and other fuels are still under study since lowest WTW CO2 emissions and overall system costs are not yet clarified. The availability of alternative fuels in large quantities will depend on the costs for production and infra-structure, and not least of all, on the market benefits of the resulting fuel / power train systems in a holistic assessment. Cost trends for conventional and alternative fuels will be discussed.