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This paper presents an efficient method for posture and movement prediction based on three-dimensional musculoskeletal models with a high level of detail. The potential applications of the technology in automotive engineering are numerous and range from simple static posture prediction of drivers and occupants to identification of complex movement patterns such as egress. We present one example of posture prediction and one example of movement prediction and conclude that the technology can reduce the need for experiments in musculoskeletal analysis and enhance the technology's applicability as an automotive design tool.