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Vacuum rotary distillation is an attractive technology for water recovery from wastewater onboard a human crewed spacecraft that includes human urine and reverse osmosis brine. To reduce specific energy consumption while purifying water in the vacuum rotary distillation technology, multistage distillations, as well as thermoelectric heat pumps, are used. A theoretical approach to the calculation of the optimal number of distillation stages is given. Test results are given for a new five-stage cascaded distiller in a system with a thermoelectric heat pump. These results include the performance parameters of the system and the water quality of the product for the process of water recovery from solutions of NaCl and human urine.